Figure 6
From: IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
Fibrillar and APO wild-type SOD-1, and APO and AI mutant forms of SOD-1 induce IL-1β and IL-6. Peripheral blood mononuclear cells of two sALS patients were stimulated by the indicated SOD-1 proteins and cytokines were measured in the supernatant after 18 h. Note positive dose-response of IL-1β and IL-6 to fibrillar and APO wild-type SOD-1(A, D), and to APO and AI forms of G37R and D101N SOD-1 (B, C, E, F) (open symbols = patient 1; closed symbols = patient 2)