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Figure 1 | Journal of Neuroinflammation

Figure 1

From: PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation

Figure 1

S100B ablation reduces cortical, but not hippocampal plaque load. Panel A contains representative micrographs of parasagittal cortical/hippocampal sections from 6 month old PSAPP and PSAPP/S100B-/- mice stained with Congo red (pink) and hematoxylin (blue) to visualize plaques and nuclei, respectively (bars = 50 μm). The histograms depict the mean congophilic plaque load (Panel B), plaque number (Panel C), and plaque size (Panel D) ± SEM in PSAPP (black bars, n = 8), and PSAPP/S100B-/- (red bars, n = 6) mice. Asterisks denote p ≤ 0.05 when compared to the PSAPP group.

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Journal of Neuroinflammation

ISSN: 1742-2094