Figure 3

Effects of FGF-2 and BDNF on hippocampal IL1β-positive cells. (A-C) Time course of the alterations in IL1β expression, expressed as percent of IL1β-positive pixels. See Figure 1 for details. Data are presented as mean ± s.e.m. for 6 animals per group. *P < 0.05, **P < 0.01 versus naïve; ^●P < 0.05, ^●●P > 0.01 versus pilo-control vector. One-way ANOVA and post-hoc Newman-Keuls test. (D-F) Representative sections showing IL1β immunohistochemistry in the CA1 region of naïve rats (D), of pilocarpine rats killed 11 days after control vector injection (E) and of pilocarpine rats 11 days after FGF2-BDNF vector injection (F). The pattern of changes observed in CA1 was identical for the entire hippocampus. Horizontal bar = 50 μm.