Table 1 Representative neurophisiological and neurophatological conditions involving IL-18

Sleep

Rat/Rabbit

[72]

Fever

Mouse

[73, 162]

Feeding

Mouse

[10, 11]

Learning and memory

Mouse

[77]

Rat

[48, 74, 75]

Human

[108, 111, 163]

Stress and HPA axis

Rat

[56, 57, 81]

Rat/Mouse

[62]

Holstein cattle

[80]

Pig

[54, 55]

Human

[136]

Neuroinflammation

Brain injury

   Hypoxia-ischemia

Mouse

[67, 84, 164–167]

Rat

[67, 168]

   Thromboembolic stroke

Mouse

[83]

   Spinal cord injury

Rat

[87]

   Focal brain ischemia

Rat

[86]

   Stroke

Mouse

[59, 85]

Human

[169]

Nerve injury

Rat

[47]

Viral infection

Chicken

[170]

Human

[59, 171]

Autoimmune neurodegenerative disease

Multiple Sclerosis

Human

[95–99, 101]

EAE

Mouse

[91, 93, 100]

Rat

[89, 90, 92, 94]

Neurodegenerative disease

Alzheimer's disease

Human

[50, 106–109, 111–114]

Parkinson's disease

Mouse

[117]

Neuropsychiatric disorders

Depression

Rat

[133]

Human

[136, 137, 139]

Schizophrenia

Human

[134, 135]

Other central actions

Excitotoxic damage

   Ataxia

Mouse

[53]

   Neurodegeneration

Mouse

[150]

Glioma

Rat

[156, 157]

Mouse

[152–155]