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Table 1 Representative neurophisiological and neurophatological conditions involving IL-18

From: Interleukin 18 in the CNS

Condition Species Citation
Behavior   
Sleep Rat/Rabbit [72]
Fever Mouse [73, 162]
Feeding Mouse [10, 11]
Learning and memory Mouse [77]
  Rat [48, 74, 75]
  Human [108, 111, 163]
Stress and HPA axis   
  Rat [56, 57, 81]
  Rat/Mouse [62]
  Holstein cattle [80]
  Pig [54, 55]
  Human [136]
Neuroinflammation   
Brain injury   
   Hypoxia-ischemia Mouse [67, 84, 164167]
  Rat [67, 168]
   Thromboembolic stroke Mouse [83]
   Spinal cord injury Rat [87]
   Focal brain ischemia Rat [86]
   Stroke Mouse [59, 85]
  Human [169]
Nerve injury Rat [47]
Viral infection Chicken [170]
  Human [59, 171]
Autoimmune neurodegenerative disease
Multiple Sclerosis Human [9599, 101]
EAE Mouse [91, 93, 100]
  Rat [89, 90, 92, 94]
Neurodegenerative disease
Alzheimer's disease Human [50, 106109, 111114]
Parkinson's disease Mouse [117]
Neuropsychiatric disorders
Depression Rat [133]
  Human [136, 137, 139]
Schizophrenia Human [134, 135]
Other central actions   
Excitotoxic damage   
   Ataxia Mouse [53]
   Neurodegeneration Mouse [150]
Glioma Rat [156, 157]
  Mouse [152155]