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Figure 5 | Journal of Neuroinflammation

Figure 5

From: β-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices

Figure 5

Effect of α1-agonist phenylephrine on neuronal cell death following lipopolysaccharide-induced sensitization to OGD in murine hippocampal slice cultures. A. Temporal development of cell damage (mean fluorescence intensity (MFI)) after 24 h LPS + 15 min OGD, phenylephrine (5 μM) +24 h LPS +15 min OGD and phenylephrine (50 μM) +24 h LPS + 15 min OGD. The same culture is shown at repeated time points of recovery. B. Cell death (MFI after 24 h LPS + 15 min OGD (white bars), phenylephrine (5 μM) +24 h LPS +15 min OGD (shaded bars), phenylephrine (50 μM) +24 h LPS + 15 min OGD (dark shaded bars), at repeated points of recovery. Data are shown as means ± SEM with n = 18. Phenylephrine (5 and 50 μM) + LPS + OGD versus LPS + OGD, p < 0.05 respectively in the CA1. Repeated-measures ANOVA with post hoc Bonferroni.

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Journal of Neuroinflammation

ISSN: 1742-2094