Figure 7
Increased VEGF and VEGFR2 but decreased VEGFR1 in MS lesions. Glial cells expressed VEGF in the rim of chronic demyelinated lesions in > 70% of the samples (asterisks, A) but there was no expression in the white matter of any of 5 control subjects (B). Glial cells (asterisks, C) and blood vessels (D) in areas of demyelination located in the center of the lesion and the rim expressed VEGFR2 in > 70% of samples, but there was minimal staining in all the normal subjects (E, arrow points to blood vessel). Blood vessels in all normal subjects expressed VEGFR1 (arrow, F) but there was a reduction in blood vessels surrounded by inflammation (arrow, G) or in the central area of the lesion (arrow, H) in the majority of subjects with MS. scale bars = 20 ÎĽm.