Figure 4
BDNF mRNA expression in hippocampus and cortex of mice after acute inflammation; effects of B 1 receptor antagonism. Effect of systemic administration of E. coli LPS (450 μg/kg, i.p., 6 h and 24 h) on BDNF mRNA expression in the hippocampus of mice submitted to a previous 5-min forced swimming session, according to assessment by real-time PCR. Influence of treatment with SSR240612 (5 mg/kg, i.p.), given 30 min beforehand. Each column represents the mean of 4 animals and vertical lines show the SEM. *P < 0.05 compared to vehicle-treated mice.