Figure 6
Pharmacokinetics and brain distribution of GTS in LPS-challenged mice. GTS was administered by an oral route (200 mg/kg, once daily) for 6 days. On the 7th day, GTS and LPS (i.p.) were administrated simultaneously. Figure.6A represents plasma concentration-time curves for the major ginsenosides (Rb1, Rb2, Rb3, Rc, Rd, Re, and Rg1) in GTS (n = = 3-4 mice per time point). Figure.6B shows the pharmacokinetic parameters of these ginsenosides including maximal concentration (Cmax), time to reach maximal concentration (Tmax), half-life time (T1/2), mean retention time (MRT) and area under the curve (AUC). Figure.6C shows a low brain exposure to these ginsenosides, the concentrations of these ginsenosides were all less than 20 ng/g wet tissue. The data are expressed as mean ± SD.