Figure 3
Subchronic DE Exposure Elevates Tau [pS199] in the Temporal and Frontal Lobes. Male Fischer 344 rats were exposed to either filtered air (control, 0 μg PM/m3 DE, n = 8), 35 μg PM/m3 DE (Low, n = 8), 100 μg PM/m3 DE (Mid Low, n = 8), 311 μg PM/m3 DE (Mid High, n = 8), or 992 μg PM/m3 DE (High, n = 8) for 6 months. Tau [pS199] protein levels were measured in the (A) Frontal and (B) Temporal lobe by ELISA. An * indicates significant difference (p < 0.05) from control animals. DE elevated Tau [pS199] at the highest concentrations of DE, demonstrating that subchronic exposure to high levels of air pollution is associated with Alzheimer disease-like pathology.