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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro

Figure 1

Release of MMP-9 and MMP-2 from brain pericytes after TNF-α treatment (1, 10 and 100 ng/mL) for 24 h. A, Representative zymograms showing MMP-9 and MMP-2 activities in the culture media of pericytes (top panel). Densitometric analysis of MMP-9 (bottom panel) and MMP-2 (data shown in the text) activities in the culture media of pericytes. B and C, Representative western blots (top panels) and densitometric analysis (bottom panels) of protein levels of MMP-9 and MMP-2, respectively, in the culture media of pericytes. Band intensities were quantified by scanning densitometry and the data are expressed as a percentage of control values (vehicle-treated pericytes). Each bar indicates mean ± S.E.M. for three experiments. * P < 0.05, *** P < 0.001, significantly different from vehicle-treated group.

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Journal of Neuroinflammation

ISSN: 1742-2094