The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat

Table 1 Levels of TNF-α, TNF-R1 and TNF-R2 proteins in the cerebral arteries in fresh vessels, in 24 and 48 h organ culture, with present and absences of IMD-0354, SB386023-b and U0126

	Fresh	24 h OC	48 h OC	IMD-0354 + 24 h OC	IMD-0354 + 48 h OC	SB386023-b + 24 h OC	SB386023-b + 48 h OC	U0126 + 24 h OC	U0126 + 48 h OC
TNF-α	100 ± 6	126 ± 1*	186 ± 10**	83 ± 7^#	119 ± 7^§	77 ± 10^#	101 ± 9^§	53 ± 8^##	67 ± 9^§§
TNF-R1	100 ± 7	139 ± 11*	197 ± 8**	115 ± 6	151 ± 8^§	105 ± 6	143 ± 8^§	118 ± 11	140 ± 6^§
TNF-R2	100 ± 9	145 ± 15*	207 ± 14**	122 ± 7	193 ± 8	125 ± 7	194 ± 10	98 ± 8^#	170 ± 9^§

Values are expressed as percentage of fresh and given as mean values ± S.E.M, n = 5.
*P < 0.05 and **P < 0.01, significant difference between fresh and culture after 24 and 48 h.
^§ P < 0.05 and ^§§ P < 0.01, significant difference between 48 h organ culture and treatment with 48 h culture + (IMD-0354, SB386023-b and U0126).
^# P < 0.05 and ^## P < 0.01, significant difference between 24 h organ culture and treatment with 24 h culture + (IMD-0354, SB386023-b and U0126).

ISSN: 1742-2094