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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence

Figure 5

Active Aβ vaccination in APPSw/NOS2-/- mice leads to increased total MMP9 expression at the cerebrovasculature. Panels A and B show representative total MMP9 immunohistochemcial staining from non-transgenic mice. Lightly stained neurons can be found throughout the brain but there is no discernable vascular staining. Panels C and D show representative total MMP9 immunohistochemcial staining from APPSw/NOS2-/- receiving KLH vaccination for 4 months. Again, there are lightly stained neurons throughout the brain but no discernable vascular staining. Panels E and F show representative total MMP9 immunohistochemcial staining from APPSw/NOS2-/- mice receiving Aβ vaccination. In addition to the lightly stained neurons these mice show extensive MMP9 immunostaining at the cerebrovasculature, specifically capillaries (indicated by arrows in panel E) and penetrating arteries (indicated by the arrow in panel F). Panels A-F magnification = 200×, scale bar panel A for A-F = 25 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094