Figure 5

Treatment with gelsolin reduces microglial activation, as assessed by ionized calcium binding adaptor molecule 1 (Iba-1) expression after burn-induced neuroinflammatory responses in the cortex 24 h postburn shown at low (A, × 200) and high (B, × 400) magnifications. Cell counting in cortex and striatum was performed to show that the increased Iba-1 levels after thermal injury were suppressed by a high dose of gelsolin 72 h postburn (C). All pictures are representative of brain sections from 3 mice for each time point. *P < 0.05 and **P < 0.01 vs. sham-injured mice; ##p < 0.01 vs. placebo mice; ++p < 0.01 vs. Gsn-L mice by ANOVA, Newman-Keuls post-hoc test. Data are means ± SD for n = 6.