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Table 3 Differentially expressed transcripts after 6 h stimulation with 20 μM curcumin + 100 ng/ml LPS versus 100 ng/ml LPS

From: Curcumin is a potent modulator of microglial gene expression and migration

Nr ID Symbol Gene Name FC
UP-REGULATED
1 80883 Ntng1 Netrin G1 86.2
2 18613 Pecam1 Platelet/endothelial cell adhesion molecule 1 11.7
3 12824 Col2a1 Collagen, type II, alpha 1 9.0
4 12653 Chgb Chromogranin B 8.1
5 14103 Fasl Fas ligand (TNF superfamily, member 6) 6.9
6 19206 Ptch1 Patched homolog 1 6.5
7 69816 Perp1 RIKEN cDNA 2010001M09 gene 5.4
8 14526 Gcg Glucagon 5.0
9 109685 Hyal3 Hyaluronoglucosaminidase 3 4.1
10 16189 Il4 Interleukin 4 3.8
11 20655 Sod1 Superoxide dismutase 1 3.5
12 19013 Ppara Peroxisome proliferator activated receptor alpha 3.1
13 20997 T Brachyuri 2.6
14 640627 Gm9789 ENSMUSG00000044227 2.6
15 16147 Ihh Indian hedgehog homolog 2.6
16 17246 Mdm2 Transformed mouse 3T3 cell double minute 2 2.5
17 99439 Duox1 Dual oxidase 1 2.3
18 257956 Olfr1307 Olfactory receptor 1307 2.3
19 14179 Fgf8 Fibroblast growth factor 8 2.1
DOWN-REGULATED
1 16193 Il6 Interleukin 6 -93.1
2 18126 Nos2 Nitric oxide synthase 2 -55.7
3 19225 Ptgs2 Prostaglandin-endoperoxide synthase 2 -17.6
4 20296 Ccl2 Chemokine (C-C motif) ligand 2 -14.7
5 12266 C3 Complement C3 -9.1
6 20846 Stat1 Signal transducers and activator of transcription 1 -7.4
7 12048 Bcl2l1 BCL2-like 1 -5.4
8 14281 Fos FBJ osteosarcoma oncogene -4.6
9 16835 Ldlr Low density lipoprotein receptor -4.1
10 16992 Lta Lymphotoxin A -3.5
11 17395 Mmp9 Matrix metallopeptidase 9 -2.2
  1. Significance analysis of triplicate microarrays was performed with a false discovery rate of 0.1%. ID, Entrez Gene ID; FC: Fold change.