Table 3 Differentially expressed transcripts after 6 h stimulation with 20 μM curcumin + 100 ng/ml LPS versus 100 ng/ml LPS
From: Curcumin is a potent modulator of microglial gene expression and migration
Nr | ID | Symbol | Gene Name | FC |
|---|---|---|---|---|
UP-REGULATED | ||||
1 | 80883 | Ntng1 | Netrin G1 | 86.2 |
2 | 18613 | Pecam1 | Platelet/endothelial cell adhesion molecule 1 | 11.7 |
3 | 12824 | Col2a1 | Collagen, type II, alpha 1 | 9.0 |
4 | 12653 | Chgb | Chromogranin B | 8.1 |
5 | 14103 | Fasl | Fas ligand (TNF superfamily, member 6) | 6.9 |
6 | 19206 | Ptch1 | Patched homolog 1 | 6.5 |
7 | 69816 | Perp1 | RIKEN cDNA 2010001M09 gene | 5.4 |
8 | 14526 | Gcg | Glucagon | 5.0 |
9 | 109685 | Hyal3 | Hyaluronoglucosaminidase 3 | 4.1 |
10 | 16189 | Il4 | Interleukin 4 | 3.8 |
11 | 20655 | Sod1 | Superoxide dismutase 1 | 3.5 |
12 | 19013 | Ppara | Peroxisome proliferator activated receptor alpha | 3.1 |
13 | 20997 | T | Brachyuri | 2.6 |
14 | 640627 | Gm9789 | ENSMUSG00000044227 | 2.6 |
15 | 16147 | Ihh | Indian hedgehog homolog | 2.6 |
16 | 17246 | Mdm2 | Transformed mouse 3T3 cell double minute 2 | 2.5 |
17 | 99439 | Duox1 | Dual oxidase 1 | 2.3 |
18 | 257956 | Olfr1307 | Olfactory receptor 1307 | 2.3 |
19 | 14179 | Fgf8 | Fibroblast growth factor 8 | 2.1 |
DOWN-REGULATED | ||||
1 | 16193 | Il6 | Interleukin 6 | -93.1 |
2 | 18126 | Nos2 | Nitric oxide synthase 2 | -55.7 |
3 | 19225 | Ptgs2 | Prostaglandin-endoperoxide synthase 2 | -17.6 |
4 | 20296 | Ccl2 | Chemokine (C-C motif) ligand 2 | -14.7 |
5 | 12266 | C3 | Complement C3 | -9.1 |
6 | 20846 | Stat1 | Signal transducers and activator of transcription 1 | -7.4 |
7 | 12048 | Bcl2l1 | BCL2-like 1 | -5.4 |
8 | 14281 | Fos | FBJ osteosarcoma oncogene | -4.6 |
9 | 16835 | Ldlr | Low density lipoprotein receptor | -4.1 |
10 | 16992 | Lta | Lymphotoxin A | -3.5 |
11 | 17395 | Mmp9 | Matrix metallopeptidase 9 | -2.2 |