Blood cytokine/chemokine levels show alterations in gene expression patterns comparable to the brain. Plasma collected from saline or LPS-preconditioned (0.8 mg/kg) mice at the time of or following 60 min MCAO was examined using a multikine ELISA (Quansys). Results indicated that pro-inflammatory cytokines IL1β, IL6 and MCP-1 are similar in saline and LPS-preconditioned mice. In contrast, LPS-preconditioned mice have significantly enhanced levels of the anti-inflammatory/type I IFN-associated cytokine and chemokine IL10 and RANTES compared to saline following MCAO. Two-way ANOVA, LPS vs. saline, *p < 0.05, n ≥ 3 per treatment.