Skip to main content

Table 3 Proliferation of PDGFRα, PDGFRβ, and IBA-1 expressing cells in wild type and NG2 null mice.

From: Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord

 

WT

KO

Total Pα positive cells

178.23 ± 20.3

127.94 ± 18.4*

Pα/BrdU positive cells

26.4 ± 2.2

10.76 ± 2.9

Mitotic indices

14.81 ± 3.1%

8.41 ± 0.6%**

Total Pβ positive cells

29.8 ± 5.7

21.91 ± 3.4*

Pβ/BrdU positive cells

4.53 ± 0.8

2.31 ± 0.9

Mitotic indices

15.2 ± 0.6%

10.52 ± 0.6%***

Total IBA-1 positive cells

217.94 ± 14.8

74.45 ± 12.3***

IBA1/BrdU positive cells

19.66 ± 3.6

4.71 ± 3.5

Mitotic indices

9.02 ± 1.2%

6.32 ± 1.8%*

  1. Total numbers of PDGFRα (Pα), PDGFRβ (Pβ), and IBA-1 positive cells, along with BrdU incorporation, were determined in 0.1 mm2 areas of the dorsal column at 7 days postsurgery. Mitotic labeling indices for OPCs, pericytes, and macrophages/microglial cells are expressed as the percentage of each cell type that is BrdU positive. Data represent the mean ± S.D. Statistically significant differences between wild type and NG2 null mice are indicated by * < 0.05; ** < 0.01; *** < 0.001.
Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094