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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Differential regional expression patterns of α-synuclein, TNF-α, and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment

Figure 2

Symptoms of motor dysfunction in mice treated with a sublethal dose (10 mg/kg b.w.) of PQ. PQ caused severe postural instability (A) and gait impairment (B). (A): The curling test evaluated asymmetry in body posture. There was severe hunched-back deviation from the vertical body axis in PQ-treated animals. (B): Representative walking footprint patterns displayed irregular stride length in consecutive steps in treated animals. Control animals followed a straight walking pathway, whereas treated animals deviated from the normal walking pathway within a confined area. (C): Bar graph indicates differential stride length of consecutive steps in PQ-treated animals compared to controls. (D): There were no significant differences in average number of steps (step frequency) for PQ-treated animals compared to vehicle-treated controls. Values in figure C and D represent mean ± SEM (n = 3). Asterisk (*) indicates a significant change in stride length, p < 0.05 (Student's t-test).

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Journal of Neuroinflammation

ISSN: 1742-2094