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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Differential regional expression patterns of α-synuclein, TNF-α, and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment

Figure 6

Dose-dependent variable effects of PQ on dopaminergic cell counts in SN. Immunopositivity for FOX3 (A) and TH (B) represent dopaminergic neuronal cells in SN during treatment of mice with different doses of PQ. Different doses of PQ (5, 10, 20, 40 and 80 mg/kg b.w.) decreased cell counts variably in SN with a maximum observed effect at a PQ dose of 10 mg/kg b.w. (a sublethal dose) (C). Details of immunohistochemistry and cell counting are described in Methods. Values are presented as mean ± SEM (n = 3). Asterisks (*) indicate significant differences (p < 0.05, ANOVA) in cell counts for different doses compared to controls. The same letter indicates nonsignificant differences and different letters indicate significant differences (p < 0.05, Student's t-test) between groups.

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Journal of Neuroinflammation

ISSN: 1742-2094