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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size

Figure 2

Systemic inflammation increases BBB damage and brain oedema independently of infarct size. A. The volume of the ischaemic damage was measured on cresyl violet (Nissl) stained serial brain sections. B. BBB damage was assessed by immunostaining for mouse IgG on free floating brain sections. Intraperitoneal LPS injection and anaphylaxis 3 hours prior to MCAo significantly augment BBB disruption at 24 hours of reperfusion (P < 0.05, One-way ANOVA, Bonferroni's post-hoc comparison). C. Oedema is expressed as percentage increase of the ipsilateral hemispheric volume compared to the contralateral hemisphere (# P < 0.05, systemic inflammatory challenges versus control conditions, Two-way ANOVA). D. Representative images show the ischaemic brain- (Nissl) or BBB (IgG) damage in different treatment groups. Data are representative of 4-5 mice/group.

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Journal of Neuroinflammation

ISSN: 1742-2094