Effect of sIL-1RI given with low dose MDMA (3 mg/kg, i.p.) on the protection against MDMA (12.5 mg/kg, i.p.)-induced loss of 5-HT transporters in ipsilateral (A) and contralateral (B) frontal cortex 7 days later. Neurotoxic MDMA reduced the number of 5-HT transporters in both sides of the frontal cortex and this was prevented by low dose MDMA given 96 h earlier. Administration of sIL-1RI (3 μg, i.c.v.) 5 min before and 3 h after low dose MDMA prevented this protection in ipsilateral but not in contralateral frontal cortex. Results shown as mean ± s.e.mean, n = 5-7. Different from saline-treated controls: *P < 0.01, **P < 0.001. Different from neurotoxic MDMA: ΔP < 0.05, ΔΔP < 0.01. Different from MDMA3/MDMA12.5: fP < 0.05. One-way ANOVA followed by Newman-Keuls test.