Effects of various MAPK inhibitors on LPS-enhanced release of IL-6 (A) and GM-CSF (B) by BMECs. BMECs were treated with LPS (100 μg/mL) for 4 hr in the presence or absence of U0126 (10 μM), SB203580 (10 μM), or SP600125 (10 μM). Values are means ± SEM (n = 5-8). **P < 0.01, significant differences from control. #
P < 0.05, ##
P < 0.01, significant differences from LPS (100 μg/mL).