Figure 4

GPE does not affect sickness, but relieves depression-like behavior induced by LPS. Mice were treated with vehicle or LPS (830 μg/kg body weight i.p.) followed 24 h later by vehicle or GPE (5 μg i.c.v.). Sickness was assessed as changes in body weight (A) and food intake (B) while sickness behavior was assessed as change in general activity, 27 h after treatment with LPS (C). Depression-like behavior was quantified as the time of immobility during the FST, 30 h after treatment with LPS, or sucrose preference (D). n = 5-6.