Loss of LPS-induced brain ischemia tolerance in MCPIP1 KO mice. Wild type and MCPIP1 knockout mice were pretreated with LPS (0.2 mg/kg) 24 hours before MCAO. (A) Infarct images obtained by TTC staining at 48 h after MCAO. The normal tissue was stained deep red and the infarct was stained milky. (B) Brain infarcts were assessed 48 hours after MCAO and quantified as percentage area of ischemic hemisphere. Values represent mean ± SD, *p < 0.05, # p < 0.01 versus wild type, n = 8 mice per group.