Figure 7

RAd-IGF-I decreases the expression of proinflammatory molecules in LPS-stimulated astrocytes. mRNA levels of IL6 (A,B), IL-1β (C,D), TNF-α (E,F) and TLR4 (G,H) in astrocytes 24 h (A,C,E,G) or 72 h (B,D,F,H) after the addition of RAd-TK/GFP or RAd-IGF-I and treated for the last 5 h with LPS. Data are presented as mean ± SEM and are expressed as percentage of control (uninfected cells treated with LPS) values. *,**, Significant differences (* P < 0.05; **P < 0.01) in comparison to the values of uninfected cells. ^§, ^§§, Significant differences (^§P < 0.05; ^§§P < 0.01) between RAd-TK/GFP and RAd-IGF-I.