Immunostaining of COX-2 in the mouse brain after ICH. Minimal COX-2 immunoreactivity was observed in neuron-like and glia-like cells in the contralateral striatum (CL). After ICH, the number of strongly COX-2-immunoreactive cells increased in the perihematomal region of the striatum; the increase started at 5 h and continued at 3 days. Scale bar, 30 μm. Insets are representative COX-2-expressing cells at higher magnification (Scale bar, 15 μm). Quantification analysis confirmed that the number of strongly COX-2-immunoreactive cells increased from 5 h to 3 days in the perihematomal region of the striatum (n = 3/group, * P < 0.05, ** P < 0.01 compared with the CL, # P < 0.01 compared with the previous time point). Values are means ± S.D.