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Table 1 Secretory/Expression Products of Endothelial Cells*

From: Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease

Extracellular matrix factors

Proteases

fibronectin

Thrombin

laminin

MMPs

collagen I, II, III, IV, VIII, XVIII

tPA

proteoglycans

Growth factors

Anti- and pro- coagulation factors

PDGF

PGI2

EDGF

thrombomodulin

FGF

AT III

IGF

heparin sulfate

TGF-β

vWF

GM-CSF

TXA2

G-CSF

thromboplastin

Vasorelaxation factors

Factor V

NO

PAF

PGI2/E2

PAI-1, PAI-2

EDHF

Inflammatory Chemokines and Cytokines

Vasoconstriction factors

IL-1, IL-6, IL-8

TXA2/F2a

LTB4, C4, D4, E4

EDCF

MCP-1, MCP-2

leukotrienes

MHC II

free radicals

CAM

endothelin

  1. *See text for references
  2. Abbreviations used: prostacyclin (PGI2), anti-thrombin III (AT III), von Willebrand factor (vWF), thromboxane A2 (TXA2), platelet-activating factor (PAF), plasminogen activator inhibitor-1 (PAI-1), plasminogen activator inhibitor-2 (PAI-2), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), leukotriene B4 (LTB4), leukotriene C4 (LTC4), leukotriene D4 (LTD4), leukotriene E4 (LTE4), monocyte chemoattractant protein-1 (MCP-1), monocyte chemoattractant protein-2 (MCP-2), major histocompatibility complex class II (MHC II), cell adhesion molecules (CAM), matrix metalloproteinases (MMPs), tissue plasminogen activator (tPA), platelet-derived growth factor (PDGF), endothelium derived growth factor (EDGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), transforming growth factor beta (TGF-β), granulocyte macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), nitric oxide (NO), prostacyclin/prostaglandin E2 (PGI2/E2), endothelium derived hyperpolarizing factor (EDHF), thromboxane A2/prostaglandin F2a (TXA2/F2a), endothelium derived contracting factor (EDCF)
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Journal of Neuroinflammation

ISSN: 1742-2094