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Table 1 Secretory/Expression Products of Endothelial Cells*

From: Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease

Extracellular matrix factors Proteases
fibronectin Thrombin
laminin MMPs
collagen I, II, III, IV, VIII, XVIII tPA
proteoglycans Growth factors
Anti- and pro- coagulation factors PDGF
PGI2 EDGF
thrombomodulin FGF
AT III IGF
heparin sulfate TGF-β
vWF GM-CSF
TXA2 G-CSF
thromboplastin Vasorelaxation factors
Factor V NO
PAF PGI2/E2
PAI-1, PAI-2 EDHF
Inflammatory Chemokines and Cytokines Vasoconstriction factors
IL-1, IL-6, IL-8 TXA2/F2a
LTB4, C4, D4, E4 EDCF
MCP-1, MCP-2 leukotrienes
MHC II free radicals
CAM endothelin
  1. *See text for references
  2. Abbreviations used: prostacyclin (PGI2), anti-thrombin III (AT III), von Willebrand factor (vWF), thromboxane A2 (TXA2), platelet-activating factor (PAF), plasminogen activator inhibitor-1 (PAI-1), plasminogen activator inhibitor-2 (PAI-2), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), leukotriene B4 (LTB4), leukotriene C4 (LTC4), leukotriene D4 (LTD4), leukotriene E4 (LTE4), monocyte chemoattractant protein-1 (MCP-1), monocyte chemoattractant protein-2 (MCP-2), major histocompatibility complex class II (MHC II), cell adhesion molecules (CAM), matrix metalloproteinases (MMPs), tissue plasminogen activator (tPA), platelet-derived growth factor (PDGF), endothelium derived growth factor (EDGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), transforming growth factor beta (TGF-β), granulocyte macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), nitric oxide (NO), prostacyclin/prostaglandin E2 (PGI2/E2), endothelium derived hyperpolarizing factor (EDHF), thromboxane A2/prostaglandin F2a (TXA2/F2a), endothelium derived contracting factor (EDCF)