Figure 6

Increased levels of C/EBPβ in brain areas with high Aβ plaque burdens from aged tg-ArcSwe mice. A) Relative abundance of C/EBPβ showing increased protein levels in forebrain of aged tg-ArcSwe mice (tg) compared to non-transgenic mice (c). B) Representative western blot showing two isoforms of C/EBPβ (LAP and LIP). Only the C/EBPβ LAP isoform was quantified. The data represent mean ± SEM for six transgenic and six control mice. 40 μg of protein lysate was loaded in each lane and β-actin was used as a loading control. *p < 0.05, significantly different from control; crm, cross-reactive material (cf., [53, 54]). C/EBPβ protein levels in hindbrain from aged mice and from both forebrain and hindbrain from young mice were below or close to detection limit. A.U., arbitrary units.