Figure 7

C/EBPδ binding activity induced by IL-1β is blocked by Aβ fibrils. A) Representative EMSA showing inhibition of IL-1β- (10 ng/ml) induced C/EBPδ binding activity in primary astro-microglial cultures exposed to fibril-enriched Aβ (10 μM) for 3 h. B) Relative abundance of C/EBPδ binding activity showing that fibril-enriched Aβ inhibits IL-1β-induced C/EBPδ binding, but has no effect on its own. The data represent mean ± SEM for two cultures derived from three to six independent experiments. *p < 0.05, **p < 0.01, significantly different from control or otherwise indicated.