Indications of Th1 and Th17 responses in cerebrospinal fluid from patients with Lyme neuroborreliosis: a large retrospective study

Table 2 CSF-albumin/S-albumin ratios and chemokine intrathecal production indices for the different patient groups^¤.

	Group 1 Confirmed NB n = 133	Group 2 Possible late NB n = 19	Group 3 Possible early NB n = 15	Group 4 Non-NB n = 96
CXCL8 index median, (range)	0.23* (0.01-2.3)	0.11 (0.01-0.5)	4.56*** (0.19-8.63)	0.16 (0-7.40)
CXCL10 index median, (range)	3.13*** (0-76.7)	0.42 (0.02-1.08)	14.4*** (5.21-96.4)	0.59 (0-10.9)
CCL22 index median, (range)	0.30*** (0-7.00)	0.07 (0-0.20)	0.20*** (0-2.00)	0.10 (0-7.00)

Chemokine index: (CSF-chemokine/S-chemokine)/(CSF-albumin/S-albumin).
NB: neuroborreliosis.
n: number of patients.
CSF: cerebrospinal fluid.
S: serum.
¤: Indices could not be calculated for group 5, since CSF-albumin/S-albumin ratios were not available for all.
The CCL22 index was multiplied by 100 due to much higher concentrations in serum.
The IL-17 index was not calculated since IL-17 was not detectable in CSF in groups 2, 3 and 4.
* significant differences compared to the non-NB group (group 4). * p < 0.01, ** p < 0.001, *** p < 0.0001.

ISSN: 1742-2094