Figure 8
Similar increased expression of the proinflammatory markers IL-1α, IL-1β, CCL2 and CD45 in 3xTgBUB and 3xTgQ-/-BUB mice compared to non-transgenic BUB mice. A. Gene expression of IL-1α, IL-1β and CCL2 in the hippocampus of 18 m old 3xTgBUB and 3xTgQ-/-BUB mice compared to the non-transgenic BUB and BUBQ-/-mice was assessed by qRT-PCR. Results are represented as individual animal scatter dot plots with mean ± SEM (BUB and BUBQ-/-, n = 3 and 3xTgBUB and 3xTgQ-/-BUB, n = 6) of fold-difference (2-ΔCt). B. Increases in IL-1α are positively correlated with increased CD45 (r = Pearson's correlation coefficient)*, p < 0.05 and **, p < 0.01.