Figure 5
From: Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia
Neuroprotection in TLR-2 KO mice after HI. Neuropathological analysis at 5 days after HI showed a significant decrease in infarct volume (A) in TLR-2 KO mice (1.162 ± 0.791 mm3, n = 15) compared to WT (2.528 ± 1.570 mm3, n = 14, p = 0.0051). There was no protection in TLR-1 KO mice (2.068 ± 0.607 mm3, n = 13). The infarct area (B) was significantly attenuated in 3 out of 4 levels throughout hippocampus in TLR-2 KO mice compared to WT. C: Representative images of level 3 of the hippocampus for the different genotypes. Data is shown as mean ± SD. *≤ 0.05, **≤ 0.01. C: Scale bar: 1 mm.