|
ALS subjects
|
El Escorial criteria
|
ALSFRS-R
|
Impairment
|
Disease duration at sample collection (mo)‡
|
|---|
|
Patient 1
|
Definite
|
27
|
Moderate
|
12
|
|
Patient 2
|
Definite
|
23
|
Severe
|
12
|
|
Patient 3
|
Definite
|
18
|
Severe
|
24
|
|
Patient 4
|
Definite
|
16
|
Severe
|
18
|
|
Patient 5
|
Definite
|
29
|
Moderate
|
12
|
|
Patient 6
|
Definite
|
29
|
Moderate
|
04
|
|
Patient 7
|
Definite
|
29
|
Moderate
|
09
|
|
Patient 8
|
Definite
|
31
|
Moderate
|
08
|
|
Patient 9
|
Definite
|
35
|
Moderate
|
24
|
|
Patient 10
|
Probable
|
34
|
Moderate
|
12
|
|
Patient 11
|
Probable
|
35
|
Moderate
|
30
|
- ALSFRS-R: ALS functional rating score-revised; Impairment was measured with ALSFRS-R. ‡ Duration of disease is the interval between appearance of first symptom of ALS and collection of sample. Median disease duration in patients with respiratory dysfunction is 12(4-30) months whereas median duration of disease was 17(3-72) months in patients without respiratory dysfunction, although the observed difference was not significant upon Mann-Whitney U analysis (p > 0.05).
