Axl-/- mice have larger inflammatory cuffs and increased demyelination in the spinal cord than WT mice. One micron Trump's fixed cross-sections of WT (a,c,e) and Axl-/- (b,d,f) spinal cords were stained with toluidine blue. a,b) Representative 5× sections of whole spinal cord. Two 20× sections with areas of infiltration and demyelination are shown for each 5× section (WT: c,e; Axl-/-: d,f). The 20× sections are labeled with an asterisk (dorsal funiculus; c,d) or arrow (lateral funiculus; e,f) denoting the corresponding area on the 5× section. g) quantitative data for the mean lesion size (mm2), see methods. Ratio of CD3+ to Iba1+ cells per lesion.