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Table 1 Summary of clinical and pathological data for the acute phase of EAE in WT and Axl-/- mice

From: Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

  WT Axl-/-
Average size of lesions (p < 0.01) 0.13 ± 0.03 0.23 ± 0.02
Iba1+ microglia/macrophages per lesion (p < 0.01) 50.3 ± 4.7 24.2 ± 1.6
Ratio of CD3+ to Iba1+ cells per lesion (p < 0.01) 1.3 ± 0.07 3.7 ± 0.26
Extent of Oil-Red-O+ debris per lesion (p < 0.01) + +++
Mean number SMI32+ axons   
   Ventral lumbar spinal cord (p < 0.05) 27.7 ± 6.3 90.1 ± 12.6
   Dorsal lumbar spinal cord (p < 0.01) 3.9 ± 0.9 123.6 ± 22.6