Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

Table 1 Summary of clinical and pathological data for the acute phase of EAE in WT and Axl-/- mice

	WT	Axl-/-
Average size of lesions (p < 0.01)	0.13 ± 0.03	0.23 ± 0.02
Iba1+ microglia/macrophages per lesion (p < 0.01)	50.3 ± 4.7	24.2 ± 1.6
Ratio of CD3+ to Iba1+ cells per lesion (p < 0.01)	1.3 ± 0.07	3.7 ± 0.26
Extent of Oil-Red-O+ debris per lesion (p < 0.01)	+	+++
Mean number SMI32+ axons
Ventral lumbar spinal cord (p < 0.05)	27.7 ± 6.3	90.1 ± 12.6
Dorsal lumbar spinal cord (p < 0.01)	3.9 ± 0.9	123.6 ± 22.6

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