Figure 3
From: Predominance of Th2 polarization by Vitamin D through a STAT6-dependent mechanism
Human PBMCs exposed to 1,25(OH)2D3 have increased GATA-3 to TBX21 ratios, associated with increased STAT6/TBX21 but not Notch1/TBX21 ratios. A) Human PBMCs cultured for 3 days with 10 ng/mL of anti-CD3 demonstrate an increase in the STAT6 to TBX21 ratios by qPCR. N = 4 subjects, mean ± SD. B) Mouse PBMCs from EAE animals demonstrate an increase in GATA-3/TBX21 and STAT6/TBX21 ratios but not Notch1/TBX21 ratios by qPCR. N = 4 animals, mean ± SD, repeated twice. *P < 0.05; **p < 0.01; ***p < 0.001 compared to controls.