Figure 2

Nitric oxide decreases leukocyte and platelet adherence and vascular leakage during Plasmodium berghei ANKA infection. Mean number of adherent leukocytes (A) and platelets (B) in pial venules, and albumin leakage in arterioles (C) and venules (D) of saline-treated (n = 6) and DPTA-NO-treated (n = 6) PbA-infected mice on day 6 of infection, and in uninfected control mice (n = 5). A total of 6-8 venules and 4-6 arterioles were analyzed per mouse. Saline-treated mice showed increased number of adherent leukocytes and platelets, as well as increased vascular permeability, and DPTA-NO treatment markedly inhibited adherence and leakage. **: p < 0.01; ***: p < 0.001; NS: non-significant.