Figure 1
From: Melittin restores proteasome function in an animal model of ALS
The effect of melittin treatment on motor activity in symptomatic hSOD1 G93A mice. 14-week-old (98 day old) hSOD1G93A mice were bilaterally treated with saline (n= 10/group, circles) or 0.1 μg/ml melittin (n= 11/group, squares) subcutaneously at ST36. Based on the results of the rotarod behavioral test for the measurement of motor function, the motor function of melittin-treated hSOD1G93A mice significantly improved compared with saline-treated hSOD1G93A 7 days after the initiation of melittin treatment. The values represent as the comparison with melittin-treated hSOD1G93A transgenic mice (**p<0.001). S: second, Con: saline-treated hSOD1G93A, MT: melittin-treated hSOD1G93A