The Effect of melittin treatment on the post-translation modification of α-synuclein in symptomatic hSOD1
G93A mice. The western blot image is representative of three independent experiments. Higher molecular weight forms of α-synuclein were expressed in spinal cord of hSOD1G93A mice, but this expression was reduced following metlittin treatment (A). The level of nitrated (B) and phosphorylated α-synuclein (C) was decreased in the brainstem and spinal cord of melittin-treated mice. The expression of HSP70 was increased by melittin treatment in the brainstem and spinal cord in hSOD1G93A mice (D). HSC70 (E) and tubulin (F) were used as loading controls.