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Table 3 Real-time PCR revealed that E2 regulated the transcription of neuroinflammatory genes in the frontal cortex of middle-aged female rats.

From: Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats

Symbol Gene name TaqMan ID RQ(E2) p
complement
C3 complement C3 Rn00566466_m1 0.70 0.02
C4b complement C4 Rn00709527_m1 0.67 0.07
defensin
Np4 defensin NP-4 precursor Rn00597762_g1 2.56 0.08
RatNP-3b defensin ratNP-3 precursor Rn01478511_gH 13.27 0.06
Ig chain
IgG-2a immonoglobulin G Rn01429839_g1 8.23 0.10
lymphokine
Ccl2 chemokine (C-C) ligand 2 Rn00580555_m1 0.52 0.06
Il6 interleukin-6 Rn00561420_m1 2.82 0.04
Tgfb1 transforming growth factor beta 1 Rn00572010_m1 0.78 0.01
MHC
RT1-Aw2 RT1 class Ib Rn03034964_u1 0.61 0.10
miscellaneous
Cx3cr1 fractalkine receptor Rn00591798_m1 0.82 0.04
Mpeg1 macrophage expressed gene 1 Rn02769865_s1 0.61 0.01
nuclear receptor
Esr1 estrogen receptor-α Rn00562166_m1 1.39 0.05
phagocytic receptor
Fcgr2b Fc fragment of IgG, receptor Rn00598391_m1 0.61 0.03
Itgam CD11b Rn00709342_m1 0.57 0.01
Toll-like receptor
Tlr4 Toll-like receptor 4 Rn00569848_m1 0.81 0.05
Tlr9 Toll-like receptor 9 Rn01640054_m1 0.74 0.07
  1. Relative quantities were the mean of six individual samples. One-way ANOVA was used to evaluate statistical significance. RQ, relative quantity.