Figure 8

Seizure-induced alteration of significant genes from cell death, cellular development, and cellular function and maintenance gene network. The top ten genes within the network shown in Figure 7 significantly altered by sarin-induced seizure. Expression of CD14 molecule, signal transducer and activator of transcription 3 (STAT3), mitogen activated protein kinase kinase 3 (MAP2K3), and lipopolysaccharide binding protein (LBP) was up-regulated at 1, 3, 3, and 6 h, respectively, after seizure onset and continued to rise over the 24-h time period. Early growth response 4 (EGR4) expression was immediately up-regulated at 0.25 h after seizure onset, peaked at 3 h, and then decreased over the remainder of the time course. A similar expression pattern was seen for protein phosphatase 1 regulatory (inhibitor) subunit 15A (PPP1R15A), prostaglandin-endoperoxide synthase 2 (PTGS2), JUN oncogene (JUN), and cAMP responsive element modulator (CREM) where expression levels peaked at 3 h, dropped slightly at 6 h, and increased at 24 h after seizure onset. CCAAT/enhancer binding protein (C/EBP) δ increased from 0.25 h to 6 h after seizure onset and had a very slight drop at 24 h.