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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin

Figure 6

Canonical pathways significantly altered across all examined brain regions of sarin-exposed seizing animals. The dataset was filtered on brain region (amygdala, hippocampus, piriform cortex, septum, or thalamus), and a two-way interaction ANOVA was used to identify genes most significantly altered in each brain region based on exposure (saline or sarin) and time after seizure onset. The significant genes from each ANOVA (p-value ≤ 0.05) were compared using a Venn diagram, and the top 800 overlapping genes that mapped to canonical pathways in the IPA Knowledge Base were analyzed. The pathways that were significantly affected across all five brain regions are shown (p < 0.05, Fisher's exact test), with a threshold of 0.05 (or 1.3 when expressed as -log(p-value)) marked by an asterisk.

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Journal of Neuroinflammation

ISSN: 1742-2094