Figure 1
From: CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease
CX3CL1 reduces 6-OHDA induced lesion volume in striatum: photomicrographs representing TH immunohistochemistry following a 6-OHDA lesion. In the dorsal striatum a noticeable decrease of TH immunoreactivity is seen in the control group (HI CX3CL1; A) as compared to the groups who received exogenous CX3CL1 for 28 days; 3 ng (B), 30 ng (C) CX3CL1 90 ng (D). Bar denotes 0.5 mm. Quantification of the TH negative zone in the striatum of 3-month-old rats as determined by the Cavalieri method of unbiased stereology, demonstrates significant decrease in the TH negative immunoreactivity when CX3CL1 was administered at the different concentrations (3, 30, and 90 ng) for 28 days (E). The group that received HI-CX3CL1 had a significant larger lesion size. These findings indicate that CX3CL1 plays a neuroprotective role in the 6-OHDA model of Parkinson disease. One way ANOVA testing [F(3,19) = 7.149, p = 0.0029]. Asterisk denotes significance (* P < 0.05) of Tukey post-hoc analysis compare to HI-CX3CL1 group.