Figure 5From: The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys Preservation of Nissl stained cells in the substantia nigra. Microphotographs of Nissl stained coronal brain sections at the level of the substantia nigra of placebo (A, a), 2.5 mg/kg (B, b), and 5 mg/kg (C, c) pioglitazone-treated hemiparkinsonian monkeys. Rectangles in A, B and C indicate the location of high magnification images a, b, c. Scale bar: A, B, C = 2 mm; a, b, c = 50 μm. D: Stereological cell quantification showed a significant preservation of Nissl positive cells in the substantia nigra ipsilateral to MPTP insult in 5 mg/kg pioglitazone-treated group compared to placebo (*ANOVA; P = 0.007).Back to article page