Figure 5

An AD mouse model with TLR4 mutation was more vulnerable to cognitive impairment as assessed in the Morris water maze. Total cumulated scores per day for escape latencies (sec) (A) and path length (cm) (B) (means ± SEM) are shown during acquisition of the hidden platform task at 9 months of age. Spatial learning was impaired in TLR4M Tg mice as shown by increases in escape latencies and path length (*P < 0.05; **P < 0.01). No difference was found between any other groups.