Figure 3

Microgliosis in the APP/PS1 model of AD positively correlated with increased Aβ plaque density with age. Serial coronal sections from 2- , 4- , 6- and 12-month old controls (C57BL/6) and age-matched transgenic animals (APP/PS1) (n = 5 to 6) were immunostained for (A) activated microglia (anti-CD68) and Aβ (anti-4G8 antibody). Representative hemi-sections are shown with select high magnification fields. (B) Immunoreactivity densities from the temporal cortex region for CD68 and 4G8 were quantified, averaged and graphed (+/−SEM) for *P <0.001 from 2- and 4-month APP/PS1 animals, ^# P <0.001 from 2-, 4-, 6- and12-month wild type animals for CD68, ^# P <0.001 from 2-, 4- and 6-month wild type mice for 4 G8, and ^$ P <0.001 from 6-month APP/PS1 animals.