Figure 9

Dasatinib infusion did not affect Aβ plaque load in the brains of APP/PS1 mice. Serial sections of right hemispheres from brains of dasatinib infused, vehicle infused, and control APP/PS1 mice were immunostained using anti-Aβ antibody (clone 4 G8) and plaque load was quantified. (A) Representative images of the temporal cortex (TC) and hippocampus (HP) from brain hemispheres are shown with select high magnification TC fields. (B) Mean optical density measurements from the CA1 region of the hippocampus as well as the temporal cortex are shown +/− SEM.