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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expression

Figure 6

Indomethacin and Nogo-A antisense treatment protects animals from TBI-induced neuronal death and axonal demyelination. The neurons from animals in different groups: (A, B) rats without TBI (sham); (C, D) TBI only; (E, F) TBI combined with the administration of Nogo-A antisense (TBI + Nogo-A antisense); (G, H) TBI combined with indomethacin administration (TBI + Indomethacin). The coronal sections (10 μm thickness) through the hippocampus were stained with either H & E or luxol fast blue (LFB) for microscopic analysis to determine the neuronal damage or axonal demyelination, respectively (n = 5 in each group). TBI, traumatic brain injury.

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Journal of Neuroinflammation

ISSN: 1742-2094