Multiplex array proteomics detects increased MMP-8 in CSF after spinal cord injury

Table 2 Simple model: two sample equal variance t -tests

ID	Response Injured	Response non-Injured	Raw P -value	BH adj. P -value	Bonferroni adj. P -value
IL-1α	418.75	349.25	0.0019	0.0287	0.3674
IL-1α	438.75	368.00	0.0024	0.0287	1.0000
Leptin	839.75	733.50	0.0005	0.0156	0.1149
Leptin	838.00	763.00	0.2189	0.3649	1.0000
B7-2/CD86	504.25	386.50	0.0115	0.0927	0.1818
B7-2/CD86	533.75	413.50	0.0038	0.0367	0.2296
GM-CSF	1223.25	1012.00	0.0132	0.0932	0.2194
GM-CSF	1204.75	1002.50	0.0012	0.0287	1.0000
IL-1β	941.50	823.75	0.0200	0.1121	0.0468
IL-1β	992.25	818.00	0.0023	0.0287	1.0000
MMP-8	36424.75	3360.25	0.0003	0.0123	0.0205
MMP-8	36255.50	3567.75	0.0002	0.0123	0.0246
TIMP-1	4181.50	1720.50	0.0028	0.0304	0.2153
TIMP-1	4099.50	1688.25	0.0022	0.0287	0.2732

Mean response by injury status with raw and adjusted P-values for significance between injured and non-injured animals. Response is the difference between the median foreground signal and the median background signal on the Cy3 channel. Raw P-values are shown with Benjamini-Hochburg adjustments. Bonferroni adjusted P-values are shown for comparison. Proteins in which changes in both technical replicates were significant at the 5% level (BH adjusted P-value) are italicized.

ISSN: 1742-2094