Figure 1

IL-17 plays an important role in bacterial clearance during S. aureus brain abscess formation. Brain abscess tissues from IL-17 receptor (IL-17R) knockout (KO) and wild-type (WT) mice (n = 5 to 8 per group) were collected at days 7 and 14 after infection. Bacterial burdens were then determined by quantitative culture. Results are expressed as colony forming units (CFU) of S. aureus per gram of wet tissue weight (mean ± SEM) combined from four independent experiments. *P < 0.05, significant differences in bacterial titers between IL-17R KO and WT mice.