Figure 1

Reduction in ICH-induced neurological deficits by UCN intraperitoneally injected post-injury. UCN was administered i.p. at doses of 2.5 μg/kg (L) or 25 μg/kg (H) 60 minutes after ICH induced by intrastriatal injection of bacterial collagenase VII-S (A) or autologous blood infusion. (B). Modified neurological severity scores (mNSS) were examined on days 0, 1, 3, and 7 post-ICH. Values are shown as mean ± SD. ***p < 0.001 in ICH + L-UCN or ICH + H-UCN groups vs. ICH + saline group; ^###p < 0.001 in ICH + L-UCN vs. ICH + H-UCN group. Data were analyzed as repeated measures by two-way ANOVA followed by Bonferroni correction.